Gestational Trophoblastic Disease
نویسندگان
چکیده
It is over 100 years since Felix Marchand identified choriocarcinoma as a tumor arising from placental villous trophoblast. In 1956, Hertz etal 1 first reported the cure of a patient with metastatic choriocarcinoma using chemotherapy. The next decade saw Hertz and colleagues at the National Institute of Health, Brewer in Chicago and Bagshawe in London develop the chemotherapeutic approach to gestational trophoblastic neoplasia that would cure the majority of patients with this fatal disease. Trophoblastic tumors are fetal allograft in maternal tissues and present unique biological, immunological and pathological problems. The screening programs for persistent trophoblastic disease following evacuation of hydatidiform mole have been instrumental in the near elimination of fatalities from sequelae following mole . Most patients with metastatic diseases are now cured and usually retain reproductive function. This is achieved with the development of sensitive assay systems to precisely measure human chorionic gonadotrophin (hCG) and with the availability of effective chemotherapy.
منابع مشابه
The Gestational Trophoblastic Diseases: A Ten Year Retrospective Study
Background Gestational trophoblastic disease (GTD) defines a heterogenenous group of interrelated lesions that arise from the trophoblastic epithelium of the placenta. There are several histologically distinct types of GTD: hydatiform mole (complete or partial), persistant/invasive gestational trophoblastic neoplasia (GTN), choriocarcinoma and placenta site trophoblastic tumors. The aim of this...
متن کاملGestational trophoblastic disease I: epidemiology, pathology, clinical presentation and diagnosis of gestational trophoblastic disease, and management of hydatidiform mole.
Gestational trophoblastic disease includes hydatidiform mole (complete and partial) and gestational trophoblastic neoplasia (invasive mole, choriocarcinoma, placental site trophoblastic tumor, and epithelioid trophoblastic tumor). The epidemiology, pathology, clinical presentation, and diagnosis of each of these trophoblastic disease variants are discussed. Particular emphasis is given to manag...
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BACKGROUND Gestational Trophoblastic Disease comprises a group of benign and malignant disorders that derive from the placenta. Using Leventhal's Common-Sense Model as a theoretical framework, this paper examines illness perception in women who have been diagnosed with this disease. METHODS Thirty-one women diagnosed with Gestational Trophoblastic Disease in a hospital in Italy were asked to ...
متن کاملGestational trophoblastic disease: presentations from the XVIIth World Congress on Gestational Trophoblastic Diseases.
The current symposium contains a selection of papers that were presented at the XVIth World Congress on Gestational Trophoblastic Diseases in Budapest, Hungary, October 16–19, 2011. The Congress was organized under the exceptional leadership of Dr. Vilmos Fulop, the Congress Chairperson, and was extraordinarily successful in showcasing the latest advances in the basic science, population studie...
متن کاملCoexisting epithelioid trophoblastic tumor and placental site trophoblastic tumor of the uterus following a term pregnancy: report of a case and review of literature.
Gestational trophoblastic neoplasms are a group of fetal trophoblastic tumors including choriocarcinomas, epithelioid trophoblastic tumors (ETTs), and placental site trophoblastic tumors (PSTTs). Mixed gestational trophoblastic neoplasms are extremely rare. The existence of mixed gestational trophoblastic neoplasms that were composed of choriocarcinoma and/or PSTT and/or ETT was also reported. ...
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